Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-131-9 | CAS number: 10042-76-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Ames test: Read across from SrCl2 to Sr(NO3)2 is envisaged due to the fact that possible effects occurred could be regarded as strontium ion related effects. Both substances (SrCl2 and Sr(NO3)2) are "very soluble" (above 10 g/L at 20°C) in water. Hence, it could be concluded that read across is possible. Nevertheless, tests on the mutagenic potential of strontium compounds in bacteria are considered dispensable for principal considerations, since inorganic metal compounds are frequently negative in this assay due to limited capacity for uptake of metal ions (Guidance on information requirements and chemical safety assessment, Chapter R.7a, p. 387; HERAG facts sheet mutagenicity, Chapter 2.1).
It is concluded that strontium nitrate did not induce micronuclei in cultured human peripheral blood lymphocytes following treatments in the absence and presence of an Aroclor induced rat liver metabolic activation system (S-9 mix). Concentrations were tested and analysed up to 2116 µg/mL.
It is concluded that strontium nitrate did not induce mutation at the tk locus of L5178Y mouse lymphoma cells when tested under the conditions employed in this study .
These conditions included treatments up to precipitating concentrations in two independent experiments, in the absence and presence of a rat liver metabolic activation system (S-9 mix).
Further testing of in vivo genetic toxicity tests is not considered necessary.
Short description of key information:
Strontium substances have been tested in bacterial reverse mutation assays, in vitro gene mutation and chromosome aberration test. The tests show a negative response, thus strontium nitrate is not to be classified as mutagenic.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Strontium nitrate could be regarded to have no mutagenicity / genotoxicity effects, tested in vitro. Hence, no classification and labelling is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
