Registration Dossier
Registration Dossier
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EC number: 214-703-7 | CAS number: 1187-93-5
Endpoint summary
Administrative data
Description of key information
Aquatic toxicity studies are not proposed by the registrant as aquatic toxicity is unlikely to occur and the feasibility of experimental determination is unlikely.
Additional information
Aquatic toxicity is anticipated to be unlikely because PMVE is not expected to distribute significantly to the aquatic compartment. PMVE is in fact a gas with a limited water solubility (31.5 mg/L) resulting in a very high Henry’s Law Constant (HLC) (32000 Pa m3/mol). The HLC of PMVE indicates that, in a system water-atmosphere, PMVE tends to rapidly leave the water phase distributing to the atmosphere, therefore, even in the hypothesis that PMVE is emitted to water, it is expected to not remain in the aqueous compartment the time sufficient to exert toxic effects on aquatic organisms. The reported water solubility value of 31.5 mg/L is itself not representative of the actual solubility of the substance in the natural environment as it was obtained with the use of laboratory conditions much more stringent (completely closed system with a PMVE saturated atmosphere) than the environmental ones. The actual solubility of PMVE in natural waters under environmental conditions is expected to be significantly lower.
For the same reason (i.e. the tendency of PMVE to rapidly distribute from water to the atmosphere), the feasibility of aquatic toxicity experimental studies is doubtful as they would be expected to be very challenging due to the technical difficulty of generating a stable concentration in water, making the possibility to finally obtain meaningful results unlikely.
The EQC Fugacity III Model confirms that essentially the whole amount of PMVE eventually released to air would tend to remain into this compartment.
In order to quantitatively evaluate the aquatic hazard profile of PMVE, despite the fact that it is expected to rapidly distribute to the atmosphere, the ECOSAR models were tried to be applied. All ECOSAR results are reported in the specific endpoints of this section however, the ECOSAR models cannot be considered reliable for the ECOSAR class of chemicals which PMVE is assigned to, since the results are based on a very limited dataset of substances which identity is often not further specified or, as for the most sensitive and critical group of the food chain the fish, the coefficient of determination R^2 is low.
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