Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-935-4 | CAS number: 112-11-8
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility for Daphnia magna (OECD 202 part 2)
Key value for chemical safety assessment
Additional information
Since no studies are available for the long-term aquatic invertebrate toxicity of isopropyl oleate (112-11-8), the assessment was based on a study conducted with the structurally most similar substance, for which data is available, Fatty acids, C16-18 and C18 unsaturated isobutyl esters (CAS No. 84988-79-4) as part of a read-across approach. This is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification section 13.
The key study conducted with Fatty acids, C16-18 and C18 unsaturated isobutyl esters (CAS No. 84988-79-4) was performed according to OECD guideline 202 part II and GLP (Wierich, 1995). The test organism Daphnia magna was exposed to the test substance in a semi-static system for 21 days, at loadings of 1 and 100 mg/L. The test solutions were prepared as water accommodated fractions (WAF). At 1 mg/L no mortality and no significant effect on reproduction was observed. At 100 mg/L reproduction was significantly increased compared to the control. Thus, the test substance had no negative effects on reproduction at the tested concentrations, and the NOELR is reported to be ≥ 100 mg/L.
Thus, based on theabove mentioned results, and due to the structural and profile similarities of the two substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no toxicological long-term effects on aquatic invertebrates are expected up tothe limit ofwater solubility for isopropyl oleate (CAS No. 112-11-8).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
