Registration Dossier
Registration Dossier
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EC number: 402-860-6 | CAS number: 110553-27-0 CG 25-1320; IRGANOX 1520; TK 12229/1
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
Adsorption to solid soil phase is expected.
Key value for chemical safety assessment
Additional information
In a GLP-study according to OECD guideline 106, the adsorption/desorption characateristics were tested for 5 soils. Adsorption of the test substance could only be determined for Eurosoil 1. For the Eurosoil 2 - 5 the values of the concentrations of the substance in equilibrium state were below the detection limit. Therefore, adsorption as well as the K’oc-values could only be estimated from the detection limit. The resulting K’oc-values ranged from >18 to >109.
Furthermore, two QSAR calculations with the EPISuite v4.11, KOCWIN v2.00 were conducted. The MCI method revealed a logKoc of 7.6 and the method using the logKow determined the logKoc to be 6.7.
In summary, the substance is expected to adsorb to the solid soil phase.
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort. According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided. For the assessment of EC 402-860-6 (Q)SAR results were used for adsorption/desorption. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment. Therefore, further experimental studies on adsorption/desorption are not provided.
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