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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Study period:
2001
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Secondary literature, original study cited.

Data source

Reference
Reference Type:
publication
Title:
Comparison of the Hemoglobin Adducts Formed by Administration of N-Methylolacrylamide and Acrylamide to Rats.
Author:
Fennell TR, Snyder RW, Krol WL, Sumner SCJ
Year:
2003
Bibliographic source:
Toxicological Sciences 71: 164-175

Materials and methods

Objective of study:
metabolism

Test material

Constituent 1
Reference substance name:
N-methylol acrylamide
IUPAC Name:
N-methylol acrylamide
Constituent 2
Reference substance name:
N-(hydroxymethyl)acrylamide
EC Number:
213-103-2
EC Name:
N-(hydroxymethyl)acrylamide
Cas Number:
924-42-5
IUPAC Name:
N-(hydroxymethyl)acrylamide
Radiolabelling:
yes
Remarks:
14-C

Test animals

Species:
rat
Sex:
male

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
N-acetyl-S-(3-hydroxymethylamino-3-oxopropyl)cysteine was the major urinary metabolite.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
A study of metabolism and disposition was performed on the structurally related N-methylol acrylamide (14C) [Mathews, 2001, cited in: Fenell, T.R. et al., Toxicological Sciences 71, 164-175 (2003)]. It was found that 79 % of an oral dose of 150 mg/kg N-methylol acrylamide was excreted in the urine (30 % of the dose unchanged, 30 % glutathione conjugate derivatives, 10 % not identified).
Executive summary:

A study on metabolism and disposition was performed on the structurally related N-methylol acrylamide (14C) [Mathews, 2001, cited in: Fenell, T.R. et al., Toxicological Sciences 71, 164-175 (2003)]. It was found that 79 % of an oral dose of 150 mg/kg N-methylol acrylamide was excreted in the urine (30 % of the dose unchanged, 30 % glutathione conjugate derivatives, 10 % not identified).