Registration Dossier
Registration Dossier
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EC number: 213-086-1 | CAS number: 923-02-4
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature, original study cited.
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparison of the Hemoglobin Adducts Formed by Administration of N-Methylolacrylamide and Acrylamide to Rats.
- Author:
- Fennell TR, Snyder RW, Krol WL, Sumner SCJ
- Year:
- 2 003
- Bibliographic source:
- Toxicological Sciences 71: 164-175
Materials and methods
- Objective of study:
- metabolism
Test material
- Reference substance name:
- N-methylol acrylamide
- IUPAC Name:
- N-methylol acrylamide
- Reference substance name:
- N-(hydroxymethyl)acrylamide
- EC Number:
- 213-103-2
- EC Name:
- N-(hydroxymethyl)acrylamide
- Cas Number:
- 924-42-5
- IUPAC Name:
- N-(hydroxymethyl)acrylamide
Constituent 1
Constituent 2
- Radiolabelling:
- yes
- Remarks:
- 14-C
Test animals
- Species:
- rat
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- N-acetyl-S-(3-hydroxymethylamino-3-oxopropyl)cysteine was the major urinary metabolite.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
A study of metabolism and disposition was performed on the structurally related N-methylol acrylamide (14C) [Mathews, 2001, cited in: Fenell, T.R. et al., Toxicological Sciences 71, 164-175 (2003)]. It was found that 79 % of an oral dose of 150 mg/kg N-methylol acrylamide was excreted in the urine (30 % of the dose unchanged, 30 % glutathione conjugate derivatives, 10 % not identified). - Executive summary:
A study on metabolism and disposition was performed on the structurally related N-methylol acrylamide (14C) [Mathews, 2001, cited in: Fenell, T.R. et al., Toxicological Sciences 71, 164-175 (2003)]. It was found that 79 % of an oral dose of 150 mg/kg N-methylol acrylamide was excreted in the urine (30 % of the dose unchanged, 30 % glutathione conjugate derivatives, 10 % not identified).
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