Registration Dossier
Registration Dossier
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EC number: 222-883-3 | CAS number: 3648-18-8
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
ErC50 > water solubility, NOEC 0.0097 mg/L, OECD 201, Rufli (1988).
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 0.001 mg/L
Additional information
Since no data are available on the substance itself information has been read across to a product of its hydrolysis, dioctyltin oxide, and structural analogues of another hydrolysis product, lauric acid. The read across substance to lauric acid are sodium laurate and decanoic acid.
The toxicity of the test material to aquatic plants (Rufi, 1988b) was determined in a study conducted to standardised guidelines using the algal species Desmodesmus subspicatus (reported as Scenedesmus subspicatus). The study was conducted using a range of concentrations, tested up to the water solubility of the test material. The concentrations of the test material were not maintained in the solutions throughout the entire 72 hour test period, results were expressed as the initial concentration. Under the conditions of the study, the test material exhibited little or no difference on the growth rate of the algae, the ErC50 of the test material is considered to be greater than the water solubility of the test material.
Information on the toxicity of sodium laurate to fresh-water algae, and decanoic acid to saltwater algae, is available in the Human and Environmental Risk Assessment (2003) report on ingredients of European household cleaning products. The 72 hour EC50 value was reported as 53 mg/L for the freshwater algae exposed to sodium laurate and 0.3 mg/L for the saltwater algae exposed to decanoic acid. No information is provided on materials and methods.
The study on dioctyltin oxide (Rufi, 1988b) was performed to the OECD guideline 201. Some deficiencies were present in the study, such as limited reporting and the concentrations of the test material were not maintained throughout the study. As such, the study was assigned a reliability score of 2 and is considered to be the key study to address this endpoint. Since there was no information on materials and methods presented in the Human and Environmental Risk Assessment (2003) report, the data were assigned a reliability score of 4.
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