Registration Dossier
Registration Dossier
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EC number: 406-750-9 | CAS number: 129757-67-1 TINUVIN 123
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test conducted according to GLP and Guideline Guideline 84/449/EWG, B.12
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.12 (Mutagenicity - In Vivo Mammalian Erythrocyte Micronucleus Test)
- Version / remarks:
- (micronucleus test)
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- Reaction mass of bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] decanedioate and 1,1'-bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] 10,10'-{octane-1,8-diylbis[oxy(2,2,6,6- tetramethylpiperidine-1,4-diyl)]} didecanedioate
- IUPAC Name:
- Reaction mass of bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] decanedioate and 1,1'-bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] 10,10'-{octane-1,8-diylbis[oxy(2,2,6,6- tetramethylpiperidine-1,4-diyl)]} didecanedioate
- Reference substance name:
- A mixture of: bis(2,2,6,6-tetramethyl-1-octyloxypiperidin-4-yl)-1,10-decanedioate; 1,8-bis[(2,2,6,6-tetramethyl-4-((2,2,6,6-tetramethyl-1-octyloxypiperidin-4-yl)-decan-1,10-dioyl)piperidin-1-yl)oxy]octane
- EC Number:
- 406-750-9
- EC Name:
- A mixture of: bis(2,2,6,6-tetramethyl-1-octyloxypiperidin-4-yl)-1,10-decanedioate; 1,8-bis[(2,2,6,6-tetramethyl-4-((2,2,6,6-tetramethyl-1-octyloxypiperidin-4-yl)-decan-1,10-dioyl)piperidin-1-yl)oxy]octane
- Cas Number:
- 129757-67-1
- Molecular formula:
- Constituent 1: C44H84N2O6 Constituent 2 : C80H150N4O12
- IUPAC Name:
- 2,2,6,6-tetramethyl-1-(octyloxy)piperidin-4-yl 2,2,6,6-tetramethyl-1-{[8-({2,2,6,6-tetramethyl-4-[(10-oxo-10-{[2,2,6,6-tetramethyl-1-(octyloxy)piperidin-4-yl]oxy}decanoyl)oxy]piperidin-1-yl}oxy)octyl]oxy}piperidin-4-yl decanedioate; 2,2,6,6-tetramethyl-1-(octyloxy)piperidin-4-yl 2,2,6,6-tetramethyl-4-{[8-({2,2,6,6-tetramethyl-1-[(10-oxo-10-{[2,2,6,6-tetramethyl-1-(octyloxy)piperidin-4-yl]oxy}decanoyl)oxy]piperidin-4-yl}oxy)octyl]oxy}piperidin-1-yl decanedioate; bis[2,2,6,6-tetramethyl-1-(octyloxy)piperidin-4-yl] decanedioate
- Reference substance name:
- Reaction mass of bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] decanedioate and 1,1'-bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] 10,10'-{octane-1,8-diylbis[oxy(2,2,6,6- tetramethylpiperidine-1,4-diyl)]} didecanedioate
- IUPAC Name:
- Reaction mass of bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] decanedioate and 1,1'-bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] 10,10'-{octane-1,8-diylbis[oxy(2,2,6,6- tetramethylpiperidine-1,4-diyl)]} didecanedioate
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- other: mus, Tif: MAGf
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- Peanut oil
- No. of animals per sex per dose:
- Male: 5000 mg/kg; No. of animals: 5; Sacrifice time: 16 hours
Male: 5000 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: 5000 mg/kg; No. of animals: 5; Sacrifice time: 48 hours
Female: 5000 mg/kg; No. of animals: 5; Sacrifice times: 16 hours
Female: 5000 mg/kg; No. of animals: 5; Sacrifice times: 24 hours
Female: 5000 mg/kg; No. of animals: 5; Sacrifice times: 48 hours
Results and discussion
Test results
- Sex:
- not specified
- Genotoxicity:
- not specified
- Toxicity:
- no effects
- Remarks:
- No lethal effects up to 5000 mg/kg. No cytotoxic effect, PCE/NCE
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
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