Registration Dossier
Registration Dossier
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EC number: 290-844-8 | CAS number: 90268-43-2
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data have been obtained from publication relative to metabolites of Sulfosuccinate of lanolin Alcohol (structural similarity).
Data source
Reference
- Reference Type:
- publication
- Title:
- Final report of the safety assessment for acetilated lanolin alcohol and related compounds
- Author:
- CIR
- Year:
- 2 011
- Bibliographic source:
- Journal of the American College of Toxicology
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Lanolin Alcohol
- IUPAC Name:
- Lanolin Alcohol
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
Lanolin is the purified secretory product of the sheep sebaceous gland. It is a complex mixture of a large number of compounds. High molecular weight esters make up approximately 87% of a typical Lanolin.The remainder of the mixture is comprised of 11% free compounds (aliphatic alcohols, sterols, fatty acids and hydrocarbons) and 2% unidentified compounds.
Lanolin alcohol is derived from lanolin via hydrolysis followed extraction. It is a mixture of alcohols comprised of about two-thirds sterols and one-fourth aliphatic alcohols. Since lanoline contain unsaturated fatty acids, alcohols, esters, sterol and terpenols, autoxidation may occur and chemical autoxidation products is unknown. However, peroxides and epoxides have been suggested as likely structures (Stutsman, 1977).
Lanolin and its derivatives are used for their emollient properties on the skin, nails and hair. Emollient act to decrease the rate of evaporation by forming a barrier or occlusive material on the skin surface permitting hydration or rehydration from the deeper layers (Kammerau et al., 1976).
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