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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1982

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4-dichloro-5-sulphamoylbenzoic acid
EC Number:
220-358-3
EC Name:
2,4-dichloro-5-sulphamoylbenzoic acid
Cas Number:
2736-23-4
Molecular formula:
C7H5Cl2NO4S
IUPAC Name:
2,4-dichloro-5-sulphamoylbenzoic acid
Test material form:
solid - liquid: suspension
Details on test material:
M12325 was supplied by Hodogaya ChemicalCo., Ltd. (Tokyo, Japan).
State: water-soluble white powder
Melting point of 232 to 233.5°C.

Test animals

Species:
mouse
Strain:
ICR
Sex:
female
Details on test animals or test system and environmental conditions:
Female weight at study initiation: 16 to 18 g

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
Remarks:
Distilled water
Analytical verification of doses or concentrations:
no
Duration of treatment / exposure:
14 days
Frequency of treatment:
Twice daily doses
Doses / concentrationsopen allclose all
Remarks:
Doses / Concentrations:
300 mg/kg bw
Basis:
no data
Remarks:
Doses / Concentrations:
1000 mg/kg bw
Basis:
no data
No. of animals per sex per dose:
10 female/dose

Examinations

Statistics:
The significance of differences in survival rate was evaluated by the Fisher exact test.

Results and discussion

Results of examinations

Clinical signs:
no effects observed
Mortality:
no mortality observed
Body weight and weight changes:
no effects observed
Food consumption and compound intake (if feeding study):
not examined
Food efficiency:
not examined
Water consumption and compound intake (if drinking water study):
not examined
Ophthalmological findings:
not examined
Haematological findings:
not examined
Clinical biochemistry findings:
not examined
Urinalysis findings:
not examined
Behaviour (functional findings):
no effects observed
Organ weight findings including organ / body weight ratios:
no effects observed
Gross pathological findings:
not examined
Histopathological findings: non-neoplastic:
not examined
Histopathological findings: neoplastic:
not examined
Details on results:
The substance at multiple doses up to 1000 mg/kg was neither lethal nor productive of significant behavioral, neurological, or autonomic nervous system abnormalities throughout the experimental period of 14 days.

Effect levels

Dose descriptor:
NOAEL
Effect level:
> 1 000 mg/kg bw/day (nominal)
Sex:
female
Remarks on result:
not determinable
Remarks:
no NOAEL identified

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
The substance at multiple doses up to 1000 mg/kg was well tolerated throughout the experimental period of 14 days in mice.