Registration Dossier
Registration Dossier
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EC number: 219-281-8 | CAS number: 2402-77-9
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Version / remarks:
- Standard plate method
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2,3-dichloropyridine
- EC Number:
- 219-281-8
- EC Name:
- 2,3-dichloropyridine
- Cas Number:
- 2402-77-9
- Molecular formula:
- C5H3Cl2N
- IUPAC Name:
- 2,3-dichloropyridine
- Reference substance name:
- 2,3-dichlorpyridine
- IUPAC Name:
- 2,3-dichlorpyridine
- Test material form:
- not specified
Constituent 1
Constituent 2
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium, other: TA98, TA100, TA97, TA102
- Species / strain / cell type:
- S. typhimurium, other: TA98, TA97, TA102
- Metabolic activation:
- without
- Metabolic activation system:
- Aroclor 1254, rat liver S-9 mix
- Test concentrations with justification for top dose:
- 10-5000 µg/plate without metabolic activation
50-7500 µg/plate with metabolic activation
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium, other: TA98, TA100, TA97, TA102
- Metabolic activation:
- without
- Genotoxicity:
- not specified
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- S. typhimurium, other: TA98, TA97, TA102
- Metabolic activation:
- with
- Genotoxicity:
- not specified
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative without metabolic activation
negative with metabolic activation
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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