Registration Dossier
Registration Dossier
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EC number: 205-527-1 | CAS number: 142-19-8
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.97 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Dose descriptor starting point:
- NOAEL
- Value:
- 84.25 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 74.3 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- NOAECcorr = NOAELoral*(1/0.38 m³/kg bw/day)*(ABSoral-rat/ABSinh-human)*(6.7 m³ (8h)/10 m³ (8h)) = 84.25 mg/kg bw/day*(1/0.38 m³/kg bw/day)*(1/2)*0.67 = 74.3 mg/m³. It is assumed, that the oral absorption rate is 50% of that of the inhalation absorption.
ABS(oral/rat) = oral absorption rate in rats, ABS(inh./human) = inhalation absorption rate in humans. - AF for dose response relationship:
- 1
- Justification:
- The dose descriptor starting point is based on a NOAEL.
- AF for differences in duration of exposure:
- 2
- Justification:
- The DNEL is based on a subchronic study (90 days).
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- AF not relevnat for inhalation route.
- AF for other interspecies differences:
- 2.5
- Justification:
- Default factor for remaining differences according to ECHA REACh Guidance.
- AF for intraspecies differences:
- 5
- Justification:
- Default factor for worker according to ECHA REACh Guidance.
- AF for the quality of the whole database:
- 1
- Justification:
- The DNEL is based on a high-quality study.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties.
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.84 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEL
- Value:
- 84.25 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 84.25 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- Dermal NOAEL = oral NOAEL*ABS(oral)/ABS(dermal) = 84.25 mg/kg bw/day *(1/1) = 84.25 mg/kg bw/day. It is assumed that oral and dermal absorption rates are equal.
- AF for dose response relationship:
- 1
- Justification:
- The dose descriptor starting point is based on a NOAEL.
- AF for differences in duration of exposure:
- 2
- Justification:
- The DNEL is based on a subchronic study (90 days).
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- The experimental animal was rat.
- AF for other interspecies differences:
- 2.5
- Justification:
- Default factor for remaining differences according to ECHA REACh Guidance.
- AF for intraspecies differences:
- 5
- Justification:
- Default factor for workers according to ECHA REACh Guidance.
- AF for the quality of the whole database:
- 1
- Justification:
- The DNEL is based on a high-quality study.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties.
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Dermal
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
The DNELs were derived from a 90-day repeated (oral: feeding) dose toxicity study with allyl heptanoate in the rat (NOAELmales ≥ 84.25 mg/kg bw/day).
There is also a 28-day repeated dose study (oral: gavage) with allyl heptanoate in the rat available. Based on macroscopic and microscopic findings in the liver at 100 mg/kg bw/day, a NOEL of 30 mg/kg bw/day was derived in this subacute study. No liver effects were seen in the 90-day feeding study at a comparative dose level of 1500 ppm (males: 84.25 mg/kg bw/day; females: 93.08 mg/kg bw/day) in the 90-day feeding study. The liver effects reported in the 28-day gavage study may be attributed to a bolus effect, which is considered to be most likely caused by one of the hydrolysis products namely allyl alcohol, which is further metabolized to acrolein. Acrolein might have diminished the capacity of liver detoxification due to the bolus effect, which then caused the observed liver toxicity.
However, bolus effects are not considered relevant in the human chemical safety assessment of allyl heptanoate. Thus the NOAEL for male rats of 84.25 mg/kg bw/day derived in the 90-day feeding study was used as dose-descriptor starting point for DNEL derivation.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.73 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Dose descriptor starting point:
- NOAEL
- Value:
- 84.25 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 36.6 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- NOAECcorr = NOAELoral*(1/1.15 m³/kg bw/day (24h)) *(ABSoral-rat/ABSinh-human) = 84.25 mg/kg bw/day*(1/1.15 m³/kg bw/day)*(1/2) = 36.6 mg/m³.
It is assumed, that the oral absorption rate is 50% of that of the inhalation absorption.
ABS(oral/rat) = oral absorption rate in rats, ABS(inh./human) = inhalation absorption rate in humans. - AF for dose response relationship:
- 1
- Justification:
- The dose descriptor starting point is based on a NOAEL.
- AF for differences in duration of exposure:
- 2
- Justification:
- The DNEL is based on a subchronic study (90 days).
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- AF not relevant for inhalation route.
- AF for other interspecies differences:
- 2.5
- Justification:
- Default factor for remaining differences according to ECHA REACh Guidance.
- AF for intraspecies differences:
- 10
- Justification:
- Default factor for general population according to ECHA REACh Guidance.
- AF for the quality of the whole database:
- 1
- Justification:
- The DNEL is based on a high-quality study.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties.
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.42 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Dose descriptor starting point:
- NOAEL
- Value:
- 84.25 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 84.25 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- Dermal NOAEL = oral NOAEL*ABS(oral)/ABS(dermal) = 84.25 mg/kg bw/day *(1/1) = 84.25 mg/kg bw/day. It is assumed that oral and dermal absorption rates are equal.
- AF for dose response relationship:
- 1
- Justification:
- The dose descriptor starting point is based on a NOAEL.
- AF for differences in duration of exposure:
- 2
- Justification:
- The DNEL is based on a subchronic study (90 days).
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- The experimental animal was rat.
- AF for other interspecies differences:
- 2.5
- Justification:
- Default factor for remaining differences according to ECHA REACh Guidance.
- AF for intraspecies differences:
- 10
- Justification:
- Default factor for general population according to ECHA REACh Guidance.
- AF for the quality of the whole database:
- 1
- Justification:
- The DNEL is based on a high-quality study.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties.
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Dermal
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.42 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Dose descriptor starting point:
- NOAEL
- Value:
- 84.25 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 84.25 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- no route-to-route extrapolation performed
- AF for dose response relationship:
- 1
- Justification:
- The dose descriptor starting point is based on a NOAEL.
- AF for differences in duration of exposure:
- 2
- Justification:
- The DNEL is based on a subchronic study (90 days).
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- The experimental animal was rat.
- AF for other interspecies differences:
- 2.5
- Justification:
- Default factor for remaining differences according to ECHA REACh Guidance.
- AF for intraspecies differences:
- 10
- Justification:
- Default factor for general population according to ECHA REACh Guidance.
- AF for the quality of the whole database:
- 1
- Justification:
- The DNEL is based on a high-quality study.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties.
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Oral
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
The DNELs were derived from a 90-day repeated (oral: feeding) dose toxicity study with allyl heptanoate in the rat (NOAELmales ≥ 84.25 mg/kg bw/day).
There is also a 28-day repeated dose study (oral: gavage) with allyl heptanoate in the rat available. Based on macroscopic and microscopic findings in the liver at 100 mg/kg bw/day, a NOEL of 30 mg/kg bw/day was derived in this subacute study. No liver effects were seen in the 90-day feeding study at a comparative dose level of 1500 ppm (males: 84.25 mg/kg bw/day; females: 93.08 mg/kg bw/day) in the 90-day feeding study. The liver effects reported in the 28-day gavage study may be attributed to a bolus effect, which is considered to be most likely caused by one of the hydrolysis products namely allyl alcohol, which is further metabolized to acrolein. Acrolein might have diminished the capacity of liver detoxification due to the bolus effect, which then caused the observed liver toxicity.
However, bolus effects are not considered relevant in the human chemical safety assessment of allyl heptanoate. Thus the NOAEL for male rats of 84.25 mg/kg bw/day derived in the 90-day feeding study was used as dose-descriptor starting point for DNEL derivation.
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