Registration Dossier
Registration Dossier
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EC number: 246-042-5 | CAS number: 24155-42-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study not well documented. Only results available.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- No information
- Year:
- 1 981
- Bibliographic source:
- Journal of Medicinal Chemistry. Vol. 24, Pg. 727, 1981 [RTECS]
Materials and methods
Test material
- Reference substance name:
- α-(2,4-dichlorophenyl)-1H-imidazole-1-ethanol
- EC Number:
- 246-042-5
- EC Name:
- α-(2,4-dichlorophenyl)-1H-imidazole-1-ethanol
- Cas Number:
- 24155-42-8
- Molecular formula:
- C11H10Cl2N2O
- IUPAC Name:
- 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- intraperitoneal
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 300 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Conclusions:
- One part of the test substance administered intraperitoneal is rapidly absorbed from the peritoneum, another part of the substance experience a first pass-effect in the liver.
This mechanism caused that the intraperitoneal bioavailability of the test substance is greater than the oral, so based on the intraperitoneal LD50 = 300 mg/kg bw value, the substance can be classified into acute oral toxicity category 3.
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