Registration Dossier
Registration Dossier
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EC number: 618-944-2 | CAS number: 93413-69-5
Storage stability and reactivity towards container material
Administrative data
Link to relevant study record(s)
Description of key information
The study (Wyeth, 1991) was divided into pyrex container and amder glass ampules.
In pyrex vessels, the only degradation product detected at pH 1 was 1-[2-(dimethylamino)-1-(4-methoxyphenyl) ethyl] cyclohexene.
In the amber glass ampules, a total of eight degradation products were detected - seven of which were identified. At low pH (1-4), the major degradation product was 1-[2-(dimethylamino)-1-(4-methoxyphenyl) ethyl] cyclohexene. At high pH (8-10), the major degradation product was 1-[1-(4-methoxyphenyl)-2-(methylamino)ethyl]cyclohexanol. From pH 5-7, the major degradation product observed was 3-methoxybenzaldehyde. However, the reaction rate was extremely slow in the pH range of 5-7.
Additional information
The study (Wyeth, 1991) was divided into pyrex container and amder glass ampules.
In pyrex vessels, the only degradation product detected at pH 1 was 1-[2-(dimethylamino)-1-(4-methoxyphenyl) ethyl] cyclohexene.
In the amber glass ampules, a total of eight degradation products were detected - seven of which were identified. At low pH (1-4), the major degradation product was 1-[2-(dimethylamino)-1-(4-methoxyphenyl) ethyl] cyclohexene. At high pH (8-10), the major degradation product was 1-[1-(4-methoxyphenyl)-2-(methylamino)ethyl]cyclohexanol. From pH 5-7, the major degradation product observed was 3-methoxybenzaldehyde. However, the reaction rate was extremely slow in the pH range of 5-7.
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