Registration Dossier
Registration Dossier
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EC number: 225-102-4 | CAS number: 4659-45-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- other: Commission Directive 2004/73 EC Annex 2c Method B.1 tris Acute toxicity- Acute Toxic Class Method
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- 2,6-dichlorobenzoyl chloride
- EC Number:
- 225-102-4
- EC Name:
- 2,6-dichlorobenzoyl chloride
- Cas Number:
- 4659-45-4
- Molecular formula:
- C7H3Cl3O
- IUPAC Name:
- 2,6-dichlorobenzoyl chloride
- Test material form:
- other: slightly yellowish liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Acclimatization : at least five days,Food : ssniff® R/M-H (V 1534), ad libitum, 12 hours light / dark cycle, Relative humidity : 50 ± 20 %, Water : tap water in plastic bottles, ad libitum, Animal maintenance : in transparent macrolon® cages (type IV) on soft wood
granulate in an air-conditioned room, 3 animals per cage
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- Application volume : 10 mL/kg body weight
- Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- The observation period following treatment lasted for 14 days. Symptoms were recorded twice
every day (in the morning and in the afternoon).
Results and discussion
- Mortality:
- No deaths occurred during the whole study
- Clinical signs:
- other: The following clinical signs were observed in the 3 animals starting between 10 - 45 minutes after the administration of 2,6-Dichlorbenzoylchlorid: uncoordinated gait and/or stilted gait, squatting posture and diarrhea. The other animals started with simi
- Gross pathology:
- The animals killed at the end of the observation period showed no macroscopically visible
changes.
Applicant's summary and conclusion
- Conclusions:
- Based on the results of this study the median lethal dose value (LD50) of
2,6-Dichlorbenzoylchlorid is greater than 2000 mg/kg body weight.
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