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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

The lethal concentration (LC50) value ofclioquinolin fish[Carassius auratus (Goldfish)] in a 96 hr study on mortality effect was found to be 103.7406 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
103.741 mg/L

Additional information

No. of studies were reviewed for Short-term toxicity to fish from reliable sources having Klimisch rating 2 .

The summary of the results are presented below

 

Sr.No

Endpoint

Effect values

Basis for effect

Duration

Species

Sources

1

LC50

103.74 mg/L

Mortality

96 hrs.

Carassius auratus

Predicted data for Target Cas:130-26-7

2

LC50

10 mg/L

Mortality

24 hrs.

Ptychocheilus oregonensis

Publication data for Target Cas:130-26-7

3

LC50

10 mg/L

Behaviour

24 hrs.

Oncorhynchus kisutch

 Publication data for Target Cas:130-26-7

 

 

Based on the studies summarized in the above table for the target substance clioquinol and the read across substance,the endpoint value was found to vary between lethal concentration between LC50 = 10 mg/L to 103 mg/L in a 24hr to 96 hrs.study on the basis of mortality effect. Based on the LC50 values, the substance may qualify for the aquatic classification .

Since the BCF value of clioquinol reported was not >= 500 as well as the substance was found to be rapidly degradable.Thus considering the from CLP Criteria for aquatic classification of the substance , it is concluded that Clioquinol could not exhibit short term toxicity to fish .