Registration Dossier
Registration Dossier
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EC number: 204-984-4 | CAS number: 130-26-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Toxicology of the Eye. 3rd ed
- Author:
- Grant, W.M.
- Year:
- 1 986
- Bibliographic source:
- Springfield, IL: Charles C. Thomas Publisher, 1986., p. 243
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Clioquinol
- EC Number:
- 204-984-4
- EC Name:
- Clioquinol
- Cas Number:
- 130-26-7
- Molecular formula:
- C9H5ClINO
- IUPAC Name:
- 5-chloro-7-iodoquinolin-8-ol
Constituent 1
Test animals / tissue source
- Species:
- human
- Strain:
- not specified
Test system
- Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks on result:
- other: irritant
- Other effects:
- An investigating committee reported in 1974 knowledge of more than a dozen children with optic neuropathy from clioquinol. Less than half had
symptoms of peripheral neuropathy
Any other information on results incl. tables
Some of the earliest suspicions of toxicity affecting vision were in relation to children who were being treated for acrodermatitis enteropathica for long periods with large doses when their vision was found to be much impaired, and optic atrophy was diagnosed.
Some children had difficulty in walking as well as poor vision. An investigating committee reported in 1974 knowledge of more than a dozen children with optic neuropathy from clioquinol. Less than half had symptoms of peripheral neuropathy.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The clioquinol irritating to the human eyes .it is found that more than a dozen children with optic neuropathy from clioquinol
- Executive summary:
The clioquinol irritating to the human eyes .it is found that more than a dozen children with optic neuropathy from clioquinol
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