Registration Dossier
Registration Dossier
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EC number: 205-812-0 | CAS number: 153-00-4
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited information on study details
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
- Report date:
- 1960
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Rats received daily test substance subcutaneously for a period of 2 weeks.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- - Name of test material (as cited in study report): metenolone acetate (ZK 5469)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- other: sesame oil and benzylbenzoate (7:3)
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 2 weeks
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
4 mg/kg bw
- No. of animals per sex per dose:
- 5/sex/dose group
- Control animals:
- other: untreated control; control with sesame oil; control with sesame oil and benzylbenzoate
Results and discussion
Effect levels
- Dose descriptor:
- dose level:
- Effect level:
- >= 4 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: no effect
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
No compound-related effects on body weight, clinical sings, organ weights and histopathological examination
Applicant's summary and conclusion
- Conclusions:
- no effects
- Executive summary:
In rats, the once daily subcutaneous administration of 4 mg metenolone acetate
(ZK 5469) to male and female animals over 2 weeks did not show any compound-related effects on body weight, clinical sings, organ weights and histopathological examination.
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