Registration Dossier
Registration Dossier
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EC number: 206-190-3 | CAS number: 306-83-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2,2-dichloro-1,1,1-trifluoroethane
- EC Number:
- 206-190-3
- EC Name:
- 2,2-dichloro-1,1,1-trifluoroethane
- Cas Number:
- 306-83-2
- Molecular formula:
- C2HCl2F3
- IUPAC Name:
- 2,2-dichloro-1,1,1-trifluoroethane
- Reference substance name:
- Ethane,2,2-dichloro-1,1,1-trifluoro-
- IUPAC Name:
- Ethane,2,2-dichloro-1,1,1-trifluoro-
- Details on test material:
- - Name of test material (as cited in study report): Ethane,2,2-dichloro-1,1,1-trifluoro-, HCFC-123
- Purity: purity not reported
Constituent 1
Constituent 2
Test animals
- Species:
- hamster
- Strain:
- other: Chinese hamster
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: no data
- Duration of exposure:
- 4 h
- Concentrations:
- 11000, 23000, 29000, 43000, 44000 ppm (nominal)
Analytical concentrations were 10000, 14000, 22000, 31000, and 26000 ppm for the 11000, 23000, 29000, 43000, and 44000 ppm groups, respectively. - No. of animals per sex per dose:
- 5/exposure group= 25 total
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 28 000 ppm
- Exp. duration:
- 4 h
Any other information on results incl. tables
All animals died at 31000 ppm (194000 mg/m3) and no mortality was observed at 26000 ppm (162500 mg/m3), indicating a steep dose-reponse curve. Signs of anaesthesia were observed in surviving animals, with full recovery upon cessation of exposure.
Applicant's summary and conclusion
- Conclusions:
- An LC50 of 28000 ppm in the Chinese hamsters following a 4 hour exposure.
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