2,5-dihydrofuran

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Non-guideline study, non-GLP, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Principles of method if other than guideline:

10 Sprague-Dawley rats per sex per dose were exposed to 4.8 or 6.0 mg/L of the test substance for 4 hours by inhalation. After exposure, the animals were observed for 14 days.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

1708-89-8

IUPAC Name:

1708-89-8

Details on test material:

- Name of test material (as cited in study report): 2,5-Dihydrofuran
- Substance No.: 77/746
- Physical state: clear liquid
- Purity: 93%

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Wiga, Sulzfeld
- Weight at study initiation: 190 and 220 g, for females and males respectively
- Diet: ad libitum, Herilan MRH (H.Eggermann KG, Rinteln/Weser)
- Water: tap water ad libitum

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Rate of air: 3 L/h
- Exposure chamber volume: 180 L

TEST ATMOSPHERE
- Brief description of analytical method used: gas chromatography
- Samples taken from breathing zone: yes

Analytical verification of test atmosphere concentrations:

yes

Duration of exposure:

4 h

Concentrations:

4.8 and 6 mg/L air

No. of animals per sex per dose:

10

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
- Frequency body weight determination: before the study, 7 days after exposure and at the end of the study

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 6 mg/L air (analytical)

Based on:

test mat.

Exp. duration:

4 h

Mortality:

No mortality observed.

Clinical signs:

other: - 4.8 mg/L: Eyelid closure - 6.0 mg/L: Eyelid closure and slightly red nose area

Body weight:

There was no difference in the body weight gain between the control group and the experimental groups.

Gross pathology:

No effects observed.