Registration Dossier
Registration Dossier
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EC number: 235-038-9 | CAS number: 12060-00-3
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Lead acetate genotoxicity was tested at four laboratories in reverse mutation assays with S. typhimurium (TA98, TA100, TA1535, TA 1537, TA1538) and E. coli (WP-2 uvrA) at concentrations from 0.3 to 333.3 ug/plate. Tests were conducted with and without metabolic activation (S9 mix).
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Lead acetate
- EC Number:
- 239-379-4
- EC Name:
- Lead acetate
- Cas Number:
- 15347-57-6
- IUPAC Name:
- lead(4+) tetraacetate
Constituent 1
Results and discussion
Test results
- Species / strain:
- other: S. typhimurium TA98, TA100, TA1535, TA1537, TA1538; E. coli WP2 uvrA
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Lead acetate was negative for genotoxicity in Salmonella and E. coli in all four laboratories tested.
Assay Method |
Compound |
Result |
Dose or concentration |
Reference |
Salmonella typhimuriumTA100, TA1535, TA1537, TA1538, TA98, reverse mutation |
Pb Acetate |
- |
333 μg/plate |
Dunkel et al. (1984) |
Escherichia coliWP-2 uvrA, reverse mutation |
Pb Acetate |
- |
333 μg/plate |
Dunkel et al. (1984) |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative - Executive summary:
Lead acetate genotoxicity was tested at four laboratories in reverse mutation assays with S. typhimurium (TA98, TA100, TA1535, TA 1537, TA1538) and E. coli (WP-2 uvrA) at concentrations from 0.3 to 333.3 ug/plate. Tests were conducted with and without metabolic activation (S9 mix). Lead acetate was negative for genotoxicity in Salmonella and E. coli in all four laboratories tested.
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