Juniper, Juniperus mexicana, ext., isomerized, acetylated

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

02-03-2015 to 27-05-2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study performed under GLP. All relevant validity criteria were met.

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7220 (Boiling Point / Boiling Range)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

inspected March 2013 ; signature: May 2013

Type of method:

differential scanning calorimetry

Key result

Boiling pt.:

>= 241 - <= 252 °C

Atm. press.:

1 029 hPa

Decomposition:

no

Remarks on result:

other: Decomposition was not reported below the boiling points of the individual constituents.

Preliminary test

The TGA-curve of the test item was determined. From 200°C upwards the weight of the sample decreased significantly. At 279°C the sample weight had decreased by 25%. After the experiment, a red/brown deposit remained in the sample container (original colour: pale yellow). The change of the colour indicated reaction and/or decomposition of the test item.

 

Main study

- Experiment 1: The DSC-curve obtained examined the melting point of the substance. During heating, an endothermic peak between 200°C and 350°C was observed. The extrapolated onset temperature of the peak was 252.33°C. The effect was most likely obtained due to boiling of the test item. After the experiment it was observed that the test item evaporated from the sample container.

- Experiment 2: To investigate the boiling peak a hermetically closed sample container was applied. The extrapolated onset temperature of the boiling peak was 374.38°C. As can be seen the endothermic peak shifted to higher temperatures. It demonstrated that boiling of the test item was the reason for the endothermic effect. Since the experiment was performed under higher pressure, the extrapolated onset is not used for calculation of the boiling temperature. After the experiment it was observed that the test item evaporated from the sample container.

- Experiment 3 was performed to determine the duplicate melting point of the substance. The extrapolated onset of the evaporation peak was 240.52°C. After the experiment it was observed that the test item was evaporated from the sample container.

- Experiment 4: Because the difference in extrapolated onsets between Experiment 1 and 3 was > 1°C, Experiment 4 was performed. The extrapolated onset of the boiling peak was 249.80°C. After the experiment it was observed that the test item evaporated from the sample container.

 

Since the test item is a mixture of components (UVCB) and a large difference was observed between the extrapolated onsets a boiling range will be given. The boiling range was determined as the lowest and highest boiling temperature obtained from Experiment 1 (252.33°C), Experiment 3 (240.52°C) and Experiment 4 (249.80°C). 

Conclusions:

The boiling temperature range of the test item was determined to be > 514 to 525 K (or 241 to 252 °C) at 1029 ±1 hPa.

Executive summary:

The boiling temperature was determined using EU Method A.2. and the Differential Scanning Calorimetry method under GLP.In a preliminary test, the TGA-curve of the test item was determined. From 200°C upwards the weight of the sample decreased significantly. At 279°C the sample weight had decreased by 25%. After the experiment, a red/brown deposit remained in the sample container (original colour: pale yellow). The change of the colour indicated reaction and/or decomposition of the test item. In the definitive study, experiment 1: the DSC-curve obtained examined the melting point of the substance. During heating, an endothermic peak between 200°C and 350°C was observed. The extrapolated onset temperature of the peak was 252.33°C. The effect was most likely obtained due to boiling of the test item. After the experiment it was observed that the test item evaporated from the sample container. Within experiment 2: to investigate the boiling peak a hermetically closed sample container was applied. The extrapolated onset temperature of the boiling peak was 374.38°C. As can be seen the endothermic peak shifted to higher temperatures. It demonstrated that boiling of the test item was the reason for the endothermic effect. Since the experiment was performed under higher pressure, the extrapolated onset is not used for calculation of the boiling temperature. After the experiment it was observed that the test item evaporated from the sample container. Experiment 3 was performed to determine the duplicate melting point of the substance. The extrapolated onset of the evaporation peak was 240.52°C. After the experiment it was observed that the test item was evaporated from the sample container. Finally within experiment 4: because the difference in extrapolated onsets between Experiment 1 and 3 was > 1°C, Experiment 4 was performed. The extrapolated onset of the boiling peak was 249.80°C. After the experiment it was observed that the test item evaporated from the sample container. Since the test item is a mixture of components (UVCB) and a large difference was observed between the extrapolated onsets a boiling range will be given. The boiling range was determined as the lowest and highest boiling temperature obtained from Experiment 1 (252.33°C), Experiment 3 (240.52°C) and Experiment 4 (249.80°C).  Under the conditions of this study, the boiling point range of the test item was determined to be > 514 to 525 K (or 241 to 252 °C) at 1029 ±1 hPa. There was no decomposition reported below the boiling point range.

Description of key information

Bp range: 241 - 252 K (or 241 - 252 °C) at 1029 hPa, EU Method A.2, Thermal Analysis : DSC Method, 2015

Additional information

Key study : EU Method A.2, 2015 : The boiling temperature was determined using EU Method A.2. and the Differential Scanning Calorimetry method under GLP.In a preliminary test, the TGA-curve of the test item was determined. From 200°C upwards the weight of the sample decreased significantly. At 279°C the sample weight had decreased by 25%. After the experiment, a red/brown deposit remained in the sample container (original colour: pale yellow). The change of the colour indicated reaction and/or decomposition of the test item. In the definitive study, experiment 1: the DSC-curve obtained examined the melting point of the substance. During heating, an endothermic peak between 200°C and 350°C was observed. The extrapolated onset temperature of the peak was 252.33°C. The effect was most likely obtained due to boiling of the test item. After the experiment it was observed that the test item evaporated from the sample container. Within experiment 2: to investigate the boiling peak a hermetically closed sample container was applied. The extrapolated onset temperature of the boiling peak was 374.38°C. As can be seen the endothermic peak shifted to higher temperatures. It demonstrated that boiling of the test item was the reason for the endothermic effect. Since the experiment was performed under higher pressure, the extrapolated onset is not used for calculation of the boiling temperature. After the experiment it was observed that the test item evaporated from the sample container. Experiment 3 was performed to determine the duplicate melting point of the substance. The extrapolated onset of the evaporation peak was 240.52°C. After the experiment it was observed that the test item was evaporated from the sample container. Finally within experiment 4: because the difference in extrapolated onsets between Experiment 1 and 3 was > 1°C, Experiment 4 was performed. The extrapolated onset of the boiling peak was 249.80°C. After the experiment it was observed that the test item evaporated from the sample container. Since the test item is a mixture of components (UVCB) and a large difference was observed between the extrapolated onsets a boiling range will be given. The boiling range was determined as the lowest and highest boiling temperature obtained from Experiment 1 (252.33°C), Experiment 3 (240.52°C) and Experiment 4 (249.80°C).  Under the conditions of this study, the boiling point range of the test item was determined to be > 514 to 525 K (or 241 to 252 °C) at 1029 ±1 hPa. There was no decomposition reported below the boiling point range.