Registration Dossier
Registration Dossier
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EC number: 617-351-6 | CAS number: 82544-13-6
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000-12-11 to 2000-12-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- noVersion available
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 5,6 beta-Epoxy-7 beta-hydroxy-15 beta,16 beta-methylene-3 beta-pivaloyloxy-5 beta-androstan-17-one
- EC Number:
- 617-351-6
- Cas Number:
- 82544-13-6
- Molecular formula:
- C25 H36 O5
- IUPAC Name:
- 5,6 beta-Epoxy-7 beta-hydroxy-15 beta,16 beta-methylene-3 beta-pivaloyloxy-5 beta-androstan-17-one
Constituent 1
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- 3.6
- Temp.:
- 25 °C
- pH:
- 7
Applicant's summary and conclusion
- Executive summary:
The n-octanol/water partition coefficient of ZK 90346 was determined according to EU Testing Guideline A.8 (HPLC method based on OECD guideline no. 117) to be
log Pow = 3.60 (95 % confidence limits 3.40 - 3.79)
which indicates high lipophilicity. The method is based on the correlation of the reversed phase retention data of the test compound with those of reference compounds with known log Pow values.
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