Registration Dossier
Registration Dossier
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EC number: 421-920-2 | CAS number: 154862-43-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP Compliance, not OECD guideline
Data source
Reference
- Reference Type:
- other: inquiry result from ECHA
- Title:
- Unnamed
- Year:
- 2 015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA-guideline 798.1175 (based on Directive 92/69/EEC,B.1)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 421-920-2
- EC Name:
- -
- Cas Number:
- 154862-43-8
- Molecular formula:
- C53-H58-O6-P2
- IUPAC Name:
- 3,9-bis[2,4-bis(2-phenylpropan-2-yl)phenoxy]-2,4,8,10-tetraoxa-3,9-diphosphaspiro[5.5]undecane
Constituent 1
Test animals
- Species:
- other: Rat, Sprague Dawley
Administration / exposure
- Vehicle:
- other: 0.5 % aqueous methylcellulose
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- Male: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 3150 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 5000 mg/kg bw; Number of animals: 5; Number of deaths:0
Female: 3150 mg/kg bw; Number of animals: 5; Number of deaths:0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: MORTALITY: All animals survived through the 14-day observation period. BODY WEIGHT: The body weight was within the normal range. ANIMAL OBSERVATION: Light colored feces were observed in all animals on day 1. Wi
- Gross pathology:
- Effects on organs:
No findings considered treatment related were noted at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
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