Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
toxicity to reproduction
Type of information:
other: Data from the Safety Data Sheet
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: 4b: secondary literature

Data source

Reference
Reference Type:
secondary source
Title:
DELTANDROSTENEDIONE (with more than 0,3% d'Androstenedione)
Author:
Sanofi Aventis
Year:
2011
Bibliographic source:
Material Safety Data Sheet
Report date:
2011

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
(3aS,3bS,9aS,11aS)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,11H,11aH-cyclopenta[a]phenanthrene-1,7-dione
EC Number:
700-663-2
Cas Number:
1035-69-4
Molecular formula:
C19H24O2
IUPAC Name:
(3aS,3bS,9aS,11aS)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,11H,11aH-cyclopenta[a]phenanthrene-1,7-dione

Results and discussion

Results: P0 (first parental generation)

Details on results (P0)

see conclusion

Results: F1 generation

Details on results (F1)

see conclusion

Overall reproductive toxicity

Reproductive effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Possible reprotoxic effects due to the androgenic activity.
The substance has been classified "H360FD: May damage fertility. May damage the unborn child", according to the 1272/2008 CLP regulation, due to the impurity Androstenedione present at a concentration > 0.3%.