Registration Dossier
Registration Dossier
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EC number: 222-079-2 | CAS number: 3338-24-7
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- Please refer to Read Across Statement attached in Section 13
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 1 026 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 800 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 1 800 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- EC50: 1.7 mg/L which is not considered significantly different from the results obtained in an international ring test (EC50 = 1.0 - 2.2 mg/L) - Validity criteria fulfilled:
- yes
- Remarks:
- Cell density increased by a factor of more than 16 during test, variation in pH < 1, results for reference substance within acceptable range, 1.7 (1.0-2.2) mg/L
- Conclusions:
- EC50(72 h) was found to be >1800 mg/L for Skeletonema costatum.
- Executive summary:
The test was performed according to the ISO 10253, under GLP compliance. Skeletonema costatum was exposed to the test material for 72 hours. EC50(72 h) growth value for the test item is 1026 mg/L
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to Read Across Statement attached in Section 13
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 261 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- growth rate
- Remarks on result:
- other: (245-278) 95% confidence interval
- Details on results:
- - Exponential growth in the control (for algal test): yes
- Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- EC50: 1.09 mg/L - Validity criteria fulfilled:
- yes
- Remarks:
- Growth rate = 1.9/day (> 1.4/day). Variation coefficient of control growth rates = 1.4 (< 5%). Mean var. coef. = 13.4% (<35%). Increase of pH > 1.5 unit from start to end for control, not considered significant. EC50 for ref. sub. = 1.09 (0.65-1.73)
- Conclusions:
- ErC50(72h) of the test substance is 261 mg/L for Pseudokirchneriella subcapitata.
Remark: the test solution contains NaOH due to the production method. - Executive summary:
The test was performed according to the OECD Guideline 201 under GLP compliance. Pseudokirchneriella subcapitata was exposed to the test material for 72 hours. EC50(72h) growth value of the test substance is 261 mg/L.
Referenceopen allclose all
Description of key information
Read-across, OECD 201, freshwater: ErC50(72h) of the test item value is determinded 261mg/L
Read-across, OECD 201, marine water: ErC50(72h) of the test item value is determinded 261mg/L, ErC10(72h) is determined 1026 mg/L
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 261 mg/L
- EC50 for marine water algae:
- 1 800 mg/L
- EC10 or NOEC for marine water algae:
- 1 026 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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