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EC number: 202-607-8 | CAS number: 97-77-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Skin irritation (comparable to OECD 404): not irritating.
Eye irritation (Draize method): not irritating.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
There are reliable studies on skin irritation with the test substance disulfiram. However, since the available data have restrictions, all available information will be used in a weight of evidence to assess the irritation potential of disulfiram. In a study addressing skin irritation, rabbits were exposed to undiluted disulfiram for 4 hours under occlusive conditions (Guillot et al., 1982). According to the OECD protocol, primary cutaneous irritation index of 0 was derived, thereby indicating that no local skin reactions in form of erythema and edema were observed. When disulfiram was tested both on intact and abraded skin similar to OECD 404, the substance was not irritating (Branch, 1983c).
A primary eye irritation study was performed similar to OECD Guideline 405 to assess the irritation potential of disulfiram (Branch, 1983d). The eyes of six New Zealand White rabbits were treated with the unchanged test material by single instillation. The eye reactions were recorded according to Draize scores (Draize 1944). Only one out of 6 animals showed remarkable conjunctival reactions at the 24 hour reading. All findings were fully reversible within 7 days. Thus, the test substance was found to be not irritating to the rabbit eye in vivo.
Justification for classification or non-classification
The available data on skin and eye irritation are conclusive but not sufficient for classification according to Directive 67/548/EEC and the CLP Regulation.
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