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Diss Factsheets
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EC number: 206-441-7 | CAS number: 342-25-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006.07.10-2006.07.14
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: OSPAR Commission 2005: Protocols on Methods for the Testing of Chemicals used in the Offshore Industry (reference number: 2005-11 [a revised version of agreement 1995-07])
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- Modified according to OSPAR Commission 2006: Protocols on Methods for the Testing of Chemicals Used in the Offshore Industry
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,4'-difluorobenzophenone
- EC Number:
- 206-441-7
- EC Name:
- 2,4'-difluorobenzophenone
- Cas Number:
- 342-25-6
- Molecular formula:
- C13H8F2O
- IUPAC Name:
- (2-fluorophenyl)(4-fluorophenyl)methanone
- Details on test material:
- 2,4'-difluorbenzophenon
Liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: (Water accomodated fraction (WAF)): 20, 50, 100, 200, 500, 1000 ml WAF/l
- Sampling method: 2 x 50 ml of stock solution
- Sample storage conditions before analysis: Freezer at -21ºC
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Cyprinodon variegatus
- Details on test organisms:
- TEST ORGANISM
- Common name: Sheephead minnow
- Source: originally obtained from a stock culture at Opus Plus Ltd.(the former ERT Orkney water Technology Centre, and cultured at DHI since June 2003. Animals from this DHI culture was used for this study
ACCLIMATION
- Acclimation conditions : no acclimatation needed, test done under same conditions at same facility as test animals was optained from.
Study design
- Test type:
- semi-static
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Test temperature:
- 20±0.5ºC
- pH:
- 7.9-8.1
- Dissolved oxygen:
- > 70%
- Salinity:
- 32 ‰
- Nominal and measured concentrations:
- Stock solution made by 1000 mg substance dissolved in 2000 ml test media. Nominal concentration: 500 mg/l.
Substance was not fully dissolved, therfore a test was taken from the middle of the volumetric flask (water accomodated fraction = WAF)
The stock solution was analysed at the beginning and by water replacement. Both times the analytical value was 37 mg/l. - Details on test conditions:
- TEST SYSTEM
- Test vessel: 2 L aquariums containing 1 L test solution
- Renewal rate of test solution (frequency/flow rate): after 48 h.
- No. of organisms per vessel: 10 - Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol, CAS No. : 591-35-5, at 2.3 mg/L.
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 7.1 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- dissolved
- Basis for effect:
- mortality (fish)
- Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- Mortality: 50% at 2.3 mg/l
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- Mortality in controls < 10 %, oxygen > 60%, mortality with reference test within acceptable range, 20-80 %
- Conclusions:
- LC50(96 h) of 2,4'-difluorobenzophenone, CAS No. 342-25-6 is 7.10 mg/L for Cyprinodon variegatus
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