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Immunotoxicity

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In vitro experiments demonstrated that strontium is able to stimulate the release of histamine from mast cells but with a lower efficiency than calcium (Foreman and Mongar, 1972; Foreman, 1977). In addition, strontium stimulated the secretion of 5-hydroxytryptamine in washed human platelets (Best et al., 1981). It was concluded that strontium activates the liberation of arachidonate from membrane phospholipids, with the subsequent biosynthesis of thromboxane A2. The addition of strontium chloride to diluted rabbit serum in vitro inhibited the bactericidal actions of the serum (Toshioka et al., 1974). This effect was attributed to the inhibition of the complement.

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