3,5-dimethylhex-1-yn-3-ol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1972

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Test done before GLP and Guidelines were established.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1972

Report date:

1972

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Single 24 hours exposure

One group of six albino rabbits weighing between 2.0 and 3.0 kg. Each was employed in this study. All animals had their backs clipped free of hair 24 hours prior to testing.
The following dosage level was used:
1000 mg/kg bw
The sample was used as supplied.
All rabbits were weighed and the correct amount of Air Products and Chemicals, Inc., Surfynol 61 was applied to the bare back of each animal, The rabbits were restrained for 24 hours at which time their backs were wiped off. The animals were observed for a fourteen day period for signs of toxicity and for mortalities. Gross autopsies were performed on all animals which died during the 14 day observation period where possible and on all survivors.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

3,5-dimethylhex-1-yn-3-ol

EC Number:

203-500-9

EC Name:

3,5-dimethylhex-1-yn-3-ol

Cas Number:

107-54-0

Molecular formula:

C8H14O

IUPAC Name:

3,5-dimethylhex-1-yn-3-ol

Test animals

Species:

rabbit

Strain:

other: albino

Sex:

not specified

Administration / exposure

Type of coverage:

not specified

Vehicle:

unchanged (no vehicle)

Details on study design:

One group of six albino rabbits weighing between 2.0 and 3.0 kg. Each was employed in this study. All animals had their backs clipped free of hair 24 hours prior to testing.
The following dosage level was used:
1000 mg/kg bw
The sample was used as supplied.
All rabbits were weighed and the correct amount of Air Products and Chemicals, Inc., Surfynol 61 was applied to the bare back of each animal, The rabbits were restrained for 24 hours at which time their backs were wiped off. The animals were observed for a fourteen day period for signs of toxicity and for mortalities. Gross autopsies were performed on all animals which died during the 14 day observation period where possible and on all survivors.

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 1 000 mg/kg bw

Based on:

test mat.

Mortality:

none

Other findings:

One hour after dosing all rabbits exhibited convulsions. All recovered and survived the 14 day observation period.
The skin over the area of administration was brownish red in color and very dry. All organs appeared normal on gross observation.

Applicant's summary and conclusion

Interpretation of results:

other: non toxic

Remarks:

Criteria used for interpretation of results: other: Guide to Precautionary Labeling of Hazardous Chemicals, Manual L-1, 7th Edition, 1970 published by the Manufacturing Chemists Association, pages 12-14

Conclusions:

Air Products and Chemicals, Inc., Surfynol 61 as tested in rabbits, has an acute intact dermal LD50 of greater than 1000 mg/kg and would be considered non toxic under the guidelines outlined in Guide to Precautionary Labeling of Hazardous Chemicals, Manual L-1, 7th Edition, 1970 published by the Manufacturing Chemists Association, pages 12-14.

Executive summary:

Air Products and Chemicals, Inc., Surfynol 61 as tested in rabbits, has an acute intact dermal LD50 of greater than 1000 mg/kg and would be considered non toxic under the guidelines outlined in Guide to Precautionary Labeling of Hazardous Chemicals, Manual L-1, 7th Edition, 1970 published by the Manufacturing Chemists Association, pages 12-14.