Registration Dossier
Registration Dossier
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EC number: 201-832-9 | CAS number: 88-45-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database.
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity by using test chemical
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- ChemIDplus
- Reference Type:
- other: Authoritative database
- Title:
- Toxicity of test chemical
- Author:
- IFA GESTIS
- Year:
- 2 018
- Bibliographic source:
- GESTIS Substance Database
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity of the given test chemical in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2,4-diaminobenzenesulphonic acid
- EC Number:
- 201-846-5
- EC Name:
- 2,4-diaminobenzenesulphonic acid
- Cas Number:
- 88-63-1
- Molecular formula:
- C6H8N2O3S
- IUPAC Name:
- 2,4-diaminobenzenesulphonic acid
- Details on test material:
- - IUPAC Name: 2,4-diaminobenzenesulphonic acid
- InChI: 1S/C6H8N2O3S/c7-4-1-2-6(5(8)3-4)12(9,10)11/h1-3H,7-8H2,(H,9,10,11)
- Smiles: O=S(=O)(O)c1c(N)cc(N)cc1
- Molecular formula :C6H8N2O3S
- Molecular weight:188.206 g/mol
- Substance type:Organic
- Physical state:Solid light brown powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 3480 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 480 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 50% mortality was observed at 3480 mg/kg bw in treated animals.
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute oral LD50 value was considered to be 3480 mg/kg bw, when rats were treated with the given test chemical via oral route.
- Executive summary:
Acute oral toxicity study of the given test chemical was conducted in rats at the dose concentration of 3480 mg/kg bw.
Animals were observed for mortality. 50% mortality was observed at 3480 mg/kg bw in treated animals.
Hence, LD50 value was considered to be 3480 mg/kg bw, when rats were treated with the given test chemical via oral route.
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