Registration Dossier
Registration Dossier
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EC number: 230-625-6 | CAS number: 7226-23-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Dipole Moments and Pharmacological Activity of Cyclic Ureas, Cyclic Thioureas, and the N,N'-Dimethylated Compounds
- Author:
- Lien, E.J. & Kumler, W.D.
- Year:
- 1 968
- Bibliographic source:
- J. Med. Chem. 11: 214-219
- Reference Type:
- publication
- Title:
- Structural Requirements for CNS Activities and Toxicities of Cyclic Ureas and Thioureas
- Author:
- Lien et al.
- Year:
- 1 982
- Bibliographic source:
- J. Taiwan Pharm. Assoc. 34(1), 46-52
- Reference Type:
- publication
- Title:
- No information
- Author:
- Miller, L.C. & Tainter, M.L.
- Year:
- 1 944
- Bibliographic source:
- Proc. Soc. Exptl. Biol. Med. 57, 261
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Tetrahydro-1,3-dimethyl-1H-pyrimidin-2-one
- EC Number:
- 230-625-6
- EC Name:
- Tetrahydro-1,3-dimethyl-1H-pyrimidin-2-one
- Cas Number:
- 7226-23-5
- Molecular formula:
- C6H12N2O
- IUPAC Name:
- tetrahydro-1,3-dimethyl-1H-pyrimidin-2-one
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: 0.2% water solution was used for dosage <= 100 mg/kg; 2% solution was used for dosage of 300 and 1000 mg/kg. For dosage > 1000 mg/kg, higher concentration and only two mice were used (limited amount of test substance)
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 1 300 mg/kg bw
- Remarks on result:
- other: LD50 was obtained by the graphic calculation of Miller and Tainter
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
