Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

OECD guideline for testing of chemicals, TG420 (2001) acute oral toxicity - fixed dose procedure
Single oral gavage
Sprague-Dawley female rats
Mortality, clinical signs and body weight changes for 14 days were monitored and gross pathology for all animals was examined.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
2 000 mg/kg bw

Additional information

300 mg/l of test article was administered to 1 female in the first step because this dose did not induce any toxic sign, 2000 mg/l was administered to another 1 female . Because there was no significant toxic sign, this dose was selected for a starting dose for the main study.

Justification for classification or non-classification

The dose of 2000 mg/kg of the test article did not induce any toxic effect. No death and no clinical signs of toxicological importance were observed during the study.No treatment-related effects on body weight development and gross pathology were observed.

AM19 was considered to be classified into GHS category 5/unclassified.