Registration Dossier
Registration Dossier
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EC number: 200-517-3 | CAS number: 61-76-7
Endpoint summary
Administrative data
Description of key information
A LD50 of 350 mg/kg bw has been determined for female rats in an acute oral toxicity study by Stockhaus and Wick (1969).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 350 mg/kg bw
Additional information
In the study of Stockhaus annd Wick (1969), three groups of five female FW 49/Biberach rats each were exposed to phenylephrine. The LD50 and the confidence limits were calculated according to Litchfield and Wilcoxon. The LD50 was determined to be 350 mg/kg bw (208 -588).
Justification for classification or non-classification
Based on the LD50 value of 350 mg/kg, phenylephrine hydrochloride needs to be classified as Xn:R22 according to the Directive 67/548/EEC and Cat 4:H302 according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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