Registration Dossier
Registration Dossier
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EC number: 235-747-3 | CAS number: 12650-88-3
Endpoint summary
Administrative data
Description of key information
Additional information
The bioconcentration potential of enzymes representing macromolecules subject to metabolism in any living organism, can generally be neglected. In particular, due to the high molecular weight of 20 kD - 80 kD, the hydrophilic properties (high water solubility, negative partition coefficient) and their immediate accessibility to metabolic processes (biotransformation) it can be excluded that detergent-based enzymes will bioconcentrate, i.e. will be present in aquatic organisms at concentrations higher than in the aqueous environment [1 and 2].
Reference
[1] HERA Human and environmental risk assessment on ingredients of household cleaning products - alpha-amylases, cellulases and lipases. 2005.
[2] HERA Human and environmental risk assessment on ingredients of household cleaning products - Subtilisins (Proteases). Edition 2.0. 2007.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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