Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
3 000 mg/kg bw
Quality of whole database:
Acute and Local Toxicity – Significant lethality was observed in mice after a single oral dose of 9 g/m2. No evidence of lethality was observed in rats or dogs treated with doses of 30 and 100 g/m2, respectively. No specific diagnostic signs were observed in rodents. At these doses the only signs seen in dogs were emesis and mucoid stools2. Oral LD50 values in the dog, mouse and rat models were >5000, 3000 and 4438 mg/kg, respectively1.

Additional information

Justification for classification or non-classification

Not classified as acute toxicity.