Registration Dossier
Registration Dossier
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EC number: 418-280-1 | CAS number: 18600-59-4 CYASORB(R) UV-3638 LIGHT STABILISER
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In vitro gene mutation study in bacteria:
The test substance Chiguard 380/Chiguard 380W was evaluated in a GLP and guideline study (OECD TK 471) bacterial gene mutation test. Here, the bactertia strains Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537 were used.The negative result with and without metabolic activation was established in the study. (1995).
In vitro chromosome aberration study in mammalian cells:
The test substance Chiguard 380/Chiguard 380W was evaluated in a GLP and guideline study (EU Method B.10) in vitro chromosome aberration test. Here, Human lymphocytes was used. The negative result with and without metabolic activation was established in the study. (1995).
In vitro gene mutation study in mammalian cells:
The test substance "CHIGUARD@ 380W" (CAS 1800 -59 -4) was also evaluated in a GLP and guideline study( OECD TK 476) in vitro gene mutation test. Mouse L5178Y cells were used. In the presence or absence of metabolic activation, the test article did not induce any increase in the mutant frequency when tested up to 5000 ug/ml using long or short period of treatment. (2012)
Short description of key information:
In Vitro:
Bacterial reverse mutation test: negative with and without metabolic activation(OECD 471).
In vitro chromosome aberration test: negative with and without metabolic activation(EU method B.10).
In vitro gene mutation test: negative with and without metabolic activation(OECD 476).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the availablethree in vitro studiesin the dossier, the substance Chiguard 380/Chiguard 380W (CAS# 18600-59-4) need not to be classified as mutagenicity when considering the criteria outlined in Annex VI of 67/548/EEC and in Annex I of 1272/2008/EC.
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