Registration Dossier
Registration Dossier
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EC number: 232-136-3 | CAS number: 7787-93-1
Endpoint summary
Administrative data
Description of key information
In a skin irritation study conducted according to OECD test guideline 404 and in compliance with GLP, dichloro(3 chloropropyl)methylsilane was corrosive to the skin of a rabbit (Hűls AG, 1997). There are no study data for irritation to the eye but the corrosive nature of the test material means that an eye irritation study (required in Section 8.2.1, Annex VIII) does not need to be conducted. The selected study is the only available skin irritation/corrosion study available for the registered substance.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The key study was the only study available. Chlorosilanes generate hydrogen chloride or hydrochloric acid in the presence of moisture and are expected to be corrosive. Dichloro(3‑chloropropyl)methylsilane hydrolyses rapidly in contact with water and moist air, releasing two moles of hydrogen chloride for each mole of parent material. The study data are consistent with these observations and irritation or corrosion would be expected to be due to the hydrolysis product.
Justification for classification or non-classification
The test substance is classified ‘Skin Corr. 1A’ with hazard statement ‘H314 Causes severe skin burns and eye damage’ according to Regulation (EC) No 1272/2008. There are no experimental data for eye irritation; it is assumed that substances that are corrosive to the skin are also damaging to the eyes. There are no experimental data for respiratory tract irritation but the additional hazard statement ‘EUH071 Corrosive to the respiratory tract' is proposed in accordance with anticipated respiratory tract damage due to the hydrolysis product HCl generated by chlorosilanes on contact with moisture.
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