Registration Dossier
Registration Dossier
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EC number: 231-198-9 | CAS number: 7446-14-2
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Urinary lead content of rats was measured with epicutaneous application of four lead compounds: lead sulfate, lead oxide, lead powder, and lead stearate.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Lead sulphate
- EC Number:
- 231-198-9
- EC Name:
- Lead sulphate
- Cas Number:
- 7446-14-2
- Molecular formula:
- H2O4S.Pb
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- petrolatum
- Doses:
- 0.4g of test substance
- Control animals:
- yes
Results and discussion
Percutaneous absorption
- Dose:
- 100 mg
- Parameter:
- percentage
- Absorption:
- ca. 16.7 %
- Remarks on result:
- other: 12 days
- Conversion factor human vs. animal skin:
- Based on Stauber et al. estimated absorption rate and the assumption of equal to or more permeability in rat skin as compared with human skin, the total absorption of lead sulfate was calculated to be about 4.8% within 24 hours of a 4.4mg application to the human skin.
Any other information on results incl. tables
Lead sulphate was absorbed more easily through rat skin. the animal model experiment showed that skinexposure to all kinds of lead compounds, including elemental lead, organic acids, and inorganic acid salts of lead, increased the amount of lead excreted in urine, that is, lead burden assuming that kidney function is normal.
Applicant's summary and conclusion
- Conclusions:
- In the condition of the study, lead sulphate was found partially water soluble and easily absorbable through the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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