Registration Dossier
Registration Dossier
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EC number: 205-457-1 | CAS number: 141-10-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meets basic scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Screening of tobacco smoke constituents for mutagenicity using the Ames' test
- Author:
- Florin I et al.
- Year:
- 1 980
- Bibliographic source:
- Toxicology, 18(3), 219-232
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Florin I et al.
- Year:
- 2 008
- Bibliographic source:
- RIFM database
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Florin I et al.
- Year:
- 2 000
- Bibliographic source:
- ECB IUCLID dataset
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Florin I et al.
- Year:
- 2 007
- Bibliographic source:
- OECD SIDS, Final 04/2007
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 6,10-dimethylundeca-3,5,9-trien-2-one
- EC Number:
- 205-457-1
- EC Name:
- 6,10-dimethylundeca-3,5,9-trien-2-one
- Cas Number:
- 141-10-6
- Molecular formula:
- C13H20O
- IUPAC Name:
- 6,10-dimethylundeca-3,5,9-trien-2-one
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- liver fraction (S-9) from Aroclor 1254 or methylcholanthrene induced rats
- Test concentrations with justification for top dose:
- 3 µmol/plate (= 577 µg/plate)
Controlsopen allclose all
- Positive control substance:
- N-ethyl-N-nitro-N-nitrosoguanidine
- Remarks:
- without metabolic activation
- Positive control substance:
- other: 2-aminoanthracene
- Remarks:
- with metabolic activation
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
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