Registration Dossier
Registration Dossier
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EC number: 202-761-6 | CAS number: 99-51-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative databases
- Title:
- Revised Robust Study Summaries and Test Plan for 1,2-dimethyl-4-nitrobenzene
- Author:
- U.S. Environmental Protection Agency
- Year:
- 2 006
- Bibliographic source:
- High Production Volume (HPV) Challenge; Fisher, J., 1975, Toxicity data for o-xylene,4-nitro. Report No. A75-138, American Cyanamid Company, Agricultural Division, Princeton, NJ.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is taken from HPV challenge program.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-nitro-o-xylene
- EC Number:
- 202-761-6
- EC Name:
- 4-nitro-o-xylene
- Cas Number:
- 99-51-4
- Molecular formula:
- C8H9NO2
- IUPAC Name:
- 4-nitro-o-xylene
- Details on test material:
- Substance Name : 4-nitro-o-xylene
Molecular Formula : C8H9NO2
Physical state : Liquid
Constituent 1
Test animals
- Species:
- rabbit
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 5 695 mg/kg bw
- Clinical signs:
- other: Details of toxic effects not reported other than lethal dose value
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Dermal toxicity test with rabbits indicates a LD50 greater than 5,695 mg/kg b.w.. Based on the results, 4-nitro-o-xylene is not likely to cause any acute toxic effects via dermal route of exposure.
- Executive summary:
Dermal toxicity test with rabbits indicates a LD50 greater than 5,695 mg/kg b.w.. Based on the results, 4-nitro-o-xylene is not likely to cause any acute toxic effects via dermal route of exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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