Registration Dossier
Registration Dossier
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EC number: 412-000-1 | CAS number: 125051-32-3 CGI 784
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD method, GLP compliance
Data source
Reference
- Reference Type:
- other: inquiry result from ECHA
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD (MAY 26, 1983) 84/449/EEC, B.12
- GLP compliance:
- yes
- Type of assay:
- other: Non-bacteriological test in vivo-6th amendment data
Test material
- Reference substance name:
- Bis(η5-cyclopentadienyl)-bis(2,6-difluoro-3-[pyrrol-1-yl]-phenyl)titanium
- EC Number:
- 412-000-1
- EC Name:
- Bis(η5-cyclopentadienyl)-bis(2,6-difluoro-3-[pyrrol-1-yl]-phenyl)titanium
- Cas Number:
- 125051-32-3
- Molecular formula:
- C30H22F4N2Ti
- IUPAC Name:
- titanium(4+) bis(2,6-difluoro-3-(1H-pyrrol-1-yl)benzen-1-ide) bis(cyclopenta-2,4-dien-1-ide)
Constituent 1
Test animals
- Species:
- other: MOUSE, Tif: MAGf (SPF)
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- CMC (0.5 %)
- Duration of treatment / exposure:
- SACRIFICE TIME 16, 24, 48
- No. of animals per sex per dose:
- 8 MALES AND 8 FEMALES
Results and discussion
Test results
- Genotoxicity:
- negative
- Toxicity:
- yes
- Remarks:
- (Doses producing toxicity: NONE TESTED UP TO 5000 mg/kg)
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
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