Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 600-709-0 | CAS number: 106006-84-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 1994
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- (S)-2-Amino-6-propionylamino-4,5,6,7-tetrahydrobenzothiazole
- Cas Number:
- 106006-84-2
- Molecular formula:
- C10 H15 N3 O S
- IUPAC Name:
- (S)-2-Amino-6-propionylamino-4,5,6,7-tetrahydrobenzothiazole
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino rats, Chbb:THOM
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: Ultra Asept syringe and stomache tube
- Vehicle:
- water
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortality occured.
- Clinical signs:
- other: After the administration of 2000 mg/kg of the test compound increased nervousness, tremor, and disclored yellow urine were recorded in males and females.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: other: German Chemicals ACT
- Conclusions:
- The compound SND 919 Propionylthiazol revealed a very low acute toxicity after peroral administration in rats, as can be documented by the maximum nonlethal dose established:
Maximum non lethal dose: m 2000 mg/kg, f 2000 mg/kg.
With an approximate LD50 >> 2000 mg/kg after oral administration in rats the compound SND 919 Propionylthiazol could be classified as nontoxic according the German Chemicals Act (Chemikaliengesetz). Thus no labelling is necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
