Registration Dossier
Registration Dossier
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EC number: 202-437-4 | CAS number: 95-64-7
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- RTECS Number : ZE9450000
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances):-MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 77,317,1980
- Reference Type:
- review article or handbook
- Title:
- DPIM : XNS000
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 007
- Bibliographic source:
- SAX (Sax's Handbook of Dangerous Industrial Materials):-MUREAV Mutation Research. 77 (1980), 317.
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- RTECS database
- GLP compliance:
- not specified
- Type of assay:
- bacterial gene mutation assay
Test material
- Reference substance name:
- 3,4-xylidine
- EC Number:
- 202-437-4
- EC Name:
- 3,4-xylidine
- Cas Number:
- 95-64-7
- Molecular formula:
- C8H11N
- IUPAC Name:
- 3,4-dimethylaniline
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: Salmonella typhimurium
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- not specified
- Metabolic activation system:
- none
- Test concentrations with justification for top dose:
- Dose Data : 5 umol/plate
Results and discussion
Test results
- Species / strain:
- bacteria, other: Salmonella typhimurium
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative - Executive summary:
Mutation in microorganisms : Bacteria - Salmonella typhimurium: 5 umol/plate
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