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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2013-02-26 to 2013-03-12
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC estimation method
Media:
soil/sewage sludge

Test material

Constituent 1
Chemical structure
Reference substance name:
N-(2-hydroxypropyl)oleamide
EC Number:
203-828-2
EC Name:
N-(2-hydroxypropyl)oleamide
Cas Number:
111-05-7
Molecular formula:
C21H41NO2
IUPAC Name:
N-(2-hydroxypropyl)oleamide
Constituent 2
Reference substance name:
N-(2-Hydroxypropyl) Oleamide
IUPAC Name:
N-(2-Hydroxypropyl) Oleamide
Test material form:
other: beige waxy solid
Details on test material:
N-(2-hydroxypropyl) Oleamide
Batch T22221 without solvent
Expiry date: 2014/05/29
Purity: 100% dry matter
Radiolabelling:
no

Study design

Test temperature:
HPLC with UV detector was used to estimate the adsorption coefficient of N-(2-hydroxypropyl) Oleamide in soil and in sewage sludge.
Analytical column: Zorbax CN 4.6 mm * 250 mm - 5 µm
(Guard column: Zorbax CN 4.6 mm * 12.5 mm - 5 µm)
Mobile phase: methanol / water (55%/45% v/v)
Wave lenght: 210 nm
Temperature: 30°C
Flow rate: 1 mL/min

HPLC method

Details on study design: HPLC method:
Measured HPLC retention data were obtained for 11 reference items (acetanilide, atrazine, monuron, 2,5-dichloroaniline, linuron, naphthalene, benzoic acid phenylester, 1,2,3 trichlorobenzene, fenthion, phenanthrene and 4,4' DDT). Based on these data, a calibration graph of Log k' versus log Koc was established to correlate the measured HPLC retention data of the test item with its adsorption coefficients (Koc) for soil and sewage sludge .

The capacity factors k' were calculated according to the following equation:
k' = (tR-t0)/t0
where:
tR: HPLC retention time in minutes of test and reference items
t0: HPLC dead time in minutes (determined with formamide)

The test item was prepared at a concentration of 500 mg/L in three replicates.The reference items have been injected before and after the test item to confirm that retention times had not drifted.

Results and discussion

Adsorption coefficient
Type:
log Koc
Value:
> 2.93 - < 4.68
Temp.:
30 °C

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
In the conditions of this HPLC test, the Log Koc value of N-(2-hydroxypropyl) Oleamide for soil and sewage sluge was determined to range from 2.93 to 4.68 at 30°C.
Executive summary:

The adsorption coefficient (Log Koc) on soil and on sewage sludge of N-(2-hydroxypropyl) Oleamide was determined using HPLC in accordance with OECD 121 guideline.

Measured HPLC retention data were obtained for 11 reference items (acetanilide, atrazine, monuron, 2,5 dichloroaniline, linuron, naphathalene, benzoic acid phenylester, 1,2,3 trichlorobenzene, fenthion, phenanthrene and 4,4' DDT). Based on these data, a calibration graph was established to correlate the measured HPLC retention data of the test item with its adsorption coefficient (Log Koc) for soil and sewage sludge .

In the conditions of this HPLC test, the Log Koc value of N-(2-hydroxypropyl) Oleamide for soil and sewage sluge was determined to range from 2.93 to 4.68 at 30°C.