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EC number: 203-828-2 | CAS number: 111-05-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013-02-26 to 2013-03-12
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
Test material
- Reference substance name:
- N-(2-hydroxypropyl)oleamide
- EC Number:
- 203-828-2
- EC Name:
- N-(2-hydroxypropyl)oleamide
- Cas Number:
- 111-05-7
- Molecular formula:
- C21H41NO2
- IUPAC Name:
- N-(2-hydroxypropyl)oleamide
- Reference substance name:
- N-(2-Hydroxypropyl) Oleamide
- IUPAC Name:
- N-(2-Hydroxypropyl) Oleamide
- Test material form:
- other: beige waxy solid
- Details on test material:
- N-(2-hydroxypropyl) Oleamide
Batch T22221 without solvent
Expiry date: 2014/05/29
Purity: 100% dry matter
Constituent 1
Constituent 2
- Radiolabelling:
- no
Study design
- Test temperature:
- HPLC with UV detector was used to estimate the adsorption coefficient of N-(2-hydroxypropyl) Oleamide in soil and in sewage sludge.
Analytical column: Zorbax CN 4.6 mm * 250 mm - 5 µm
(Guard column: Zorbax CN 4.6 mm * 12.5 mm - 5 µm)
Mobile phase: methanol / water (55%/45% v/v)
Wave lenght: 210 nm
Temperature: 30°C
Flow rate: 1 mL/min
HPLC method
- Details on study design: HPLC method:
- Measured HPLC retention data were obtained for 11 reference items (acetanilide, atrazine, monuron, 2,5-dichloroaniline, linuron, naphthalene, benzoic acid phenylester, 1,2,3 trichlorobenzene, fenthion, phenanthrene and 4,4' DDT). Based on these data, a calibration graph of Log k' versus log Koc was established to correlate the measured HPLC retention data of the test item with its adsorption coefficients (Koc) for soil and sewage sludge .
The capacity factors k' were calculated according to the following equation:
k' = (tR-t0)/t0
where:
tR: HPLC retention time in minutes of test and reference items
t0: HPLC dead time in minutes (determined with formamide)
The test item was prepared at a concentration of 500 mg/L in three replicates.The reference items have been injected before and after the test item to confirm that retention times had not drifted.
Results and discussion
Adsorption coefficient
- Type:
- log Koc
- Value:
- > 2.93 - < 4.68
- Temp.:
- 30 °C
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- In the conditions of this HPLC test, the Log Koc value of N-(2-hydroxypropyl) Oleamide for soil and sewage sluge was determined to range from 2.93 to 4.68 at 30°C.
- Executive summary:
The adsorption coefficient (Log Koc) on soil and on sewage sludge of N-(2-hydroxypropyl) Oleamide was determined using HPLC in accordance with OECD 121 guideline.
Measured HPLC retention data were obtained for 11 reference items (acetanilide, atrazine, monuron, 2,5 dichloroaniline, linuron, naphathalene, benzoic acid phenylester, 1,2,3 trichlorobenzene, fenthion, phenanthrene and 4,4' DDT). Based on these data, a calibration graph was established to correlate the measured HPLC retention data of the test item with its adsorption coefficient (Log Koc) for soil and sewage sludge .
In the conditions of this HPLC test, the Log Koc value of N-(2-hydroxypropyl) Oleamide for soil and sewage sluge was determined to range from 2.93 to 4.68 at 30°C.
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