Registration Dossier
Registration Dossier
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EC number: 201-100-9 | CAS number: 78-27-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1962
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth HF, Carpenter CP, Weil CS et al.
- Year:
- 1 962
- Bibliographic source:
- Am Ind Hyg Assoc J 23: 95-107
Materials and methods
- Principles of method if other than guideline:
- Method: other: Smyth/Carpenter
- GLP compliance:
- no
- Remarks:
- prior to GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-ethynylcyclohexanol
- EC Number:
- 201-100-9
- EC Name:
- 1-ethynylcyclohexanol
- Cas Number:
- 78-27-3
- Molecular formula:
- C8H12O
- IUPAC Name:
- 1-ethynylcyclohexanol
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: young adult (based on body weight)
- Weight at study initiation: 2.5 - 3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- Penetration of rabbit skin was estimated by the one-day cuff method of Draize and associates. The fur was closely clipped over the entire trunk, and the dose retained beneath an impervious plastic film.
- Duration of exposure:
- 24 hours
- Doses:
- up to 20 mL/kg bw
- No. of animals per sex per dose:
- 4 animals
- Control animals:
- not specified
- Details on study design:
- After 24 hours contact the film was removed. Mortality was considered complete after 14 additional days.
- Duration of observation period following administration: 14 days - Statistics:
- The most probable LD50 was estimated by the methods of Thompson (1947) and Weil (1952).
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 000 mg/kg bw
- Remarks on result:
- other: reported as 1.00 mL/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 0.68 - <= 1.48 mL/kg bw
- Mortality:
- Death occurred within 14 days, no detailed information provided.
- Clinical signs:
- other: No information provided
- Gross pathology:
- No information provided
Any other information on results incl. tables
24 h exposure time, deaths within 14 days. Limits of +/- 1.96 standard deviation using the method of Thompson: 680 - 1480 mg/kg bw. Original LD50 given as 1.0 mL/kg bw.
Applicant's summary and conclusion
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