Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 209-578-0 | CAS number: 586-62-9
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2013
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Rationale for reliability incl. deficiencies DEREK is a validated (Q)SAR software, widely used to predict genotoxicity properties
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- other: Report from DEREK software
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6, May 2008
- Deviations:
- no
- Principles of method if other than guideline:
- not aplicable
- Type of assay:
- other: QSAR
Test material
- Reference substance name:
- p-mentha-1,4(8)-diene
- EC Number:
- 209-578-0
- EC Name:
- p-mentha-1,4(8)-diene
- Cas Number:
- 586-62-9
- Molecular formula:
- C10H16
- IUPAC Name:
- 4-isopropylidene-1-methylcyclohexene
- Details on test material:
- SMILES: C/C(C)=C1CCC(C)=CC/1
Constituent 1
Test animals
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Vehicle:
- no data
- Details on exposure:
- no data
- Duration of treatment / exposure:
- no data
- Frequency of treatment:
- no data
- Post exposure period:
- no data
- No. of animals per sex per dose:
- no data
- Positive control(s):
- no data
Examinations
- Tissues and cell types examined:
- no data
- Details of tissue and slide preparation:
- no data
- Evaluation criteria:
- no data
- Statistics:
- no data
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- not applicable
- Positive controls validity:
- not applicable
- Additional information on results:
- no data
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
No structural alert was identified for terpinolene for chromosome damage endpoint. - Executive summary:
DEREK software (v3.0.1) was used to predict the chromosome damage endpoint of terpinolene monoconstituent. No structural alert was identified for terpinolene for chromosome damage endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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