Registration Dossier

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
Toxicity and metabolism of ortho-, meta- and para-terphenyls
Author:
Cornish HH, Bahor RE, Ryan RC
Year:
1962
Bibliographic source:
American Industrial Hygiene Association Journal, Volume 23, Issue 5, pp 372-378

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
ortho-terphenyl
IUPAC Name:
ortho-terphenyl
Constituent 2
Reference substance name:
meta-terphenyl
IUPAC Name:
meta-terphenyl
Constituent 3
Reference substance name:
para-terphenyl
IUPAC Name:
para-terphenyl

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: feed
Duration and frequency of treatment / exposure:
- acute studies
- 30 day feeding studies

Results and discussion

Applicant's summary and conclusion

Executive summary:

The results indicated suggested that continued ingestion (30 -days via food) could result in liver and kidney damage. The major identified metabolites of o- and m-terphenyl are glucosiduronic acids and phenols. Para-terphenyl on the other hand was poorly absorbed and a large proportion of that substance was excreted in the feces.