Butyl chloroformate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Non-GLP non-guideline, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment.

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1970

Report date:

1970

Reference 2

Reference Type:

other: English translation (summary)

Title:

Unnamed

Year:

2005

Report date:

2005

Materials and methods

Principles of method if other than guideline:

Ten rats were exposed to the test substance for 1 hour via inhalation. After an exposure period of 14 days animals were necropsied.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Butyl chloroformate

EC Number:

209-750-5

EC Name:

Butyl chloroformate

Cas Number:

592-34-7

Molecular formula:

C5H9ClO2

IUPAC Name:

butyl carbonochloridate

Details on test material:

- Name of the test substance used in the study report: n-Butylchlorkohlensäureester; Chloroformic acid butyl ester
- Physical state: liquid

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

- Weight at study initiation (mean): Males: 158 g; Females 136 g

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

not specified

Vehicle:

not specified

Details on inhalation exposure:

4185 L/h

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

1 h

Concentrations:

about 200 ppm

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 200 ppm

Based on:

test mat.

Exp. duration:

1 h

Mortality:

4 out of 10 animals exposed to 200 ppm died.

Clinical signs:

other: Eyelid closure, after a few minutes forced breathing, and partially thoracic breathing was observed. In the first days after exposure no abnormal signs were observed. However, on the sixth day of the observation period 3 animals died. One animal showed ga

Body weight:

- Weight at start study: Males: 158 g; Females 136 g
- Weight at end study: Males: 201.7 g; Females 178.3 g

Gross pathology:

- Animals that died: Pulmonary emphysema
- Sacrificed animals: no effects observed