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Description of key information

No experimental toxicokinetic study is available on Triclyclodecane dimethanol diacrylate. However, as per REACH guidance document R7.C (May 2008), information on absorption, distribution, metabolisation and excretion may be deduced from the physicochemical properties.
Based on the toxicological data and the physicochemical properties, the absorption of Triclyclodecane dimethanol diacrylate is expected to be low by oral route, dermal route and inhalation.

Key value for chemical safety assessment

Additional information

No experimental toxicokinetic study is available on Triclyclodecane dimethanol diacrylate. However, as per REACH guidance document R7.C (May 2008), information on absorption, distribution, metabolisation and excretion may be deduced from the physicochemical properties, including:

-Mean molecular weight: 304.4 g/mol

-Water solubility: 9,78 mg/L (20°C) (slightly soluble)

-Partition coefficient Log Kow: 4,64

-Vapour pressure: 0.0274 Pa (25°C)

 

ABSORPTION

The high value of log Kow (>4) and the low solubility (<100 mg/L) of Triclyclodecane dimethanol diacrylate are favorable for a low oral absorption. Indeed, no clinical effects or mortality were observed after one single administration (2000 mg/kg) of Triclyclodecane dimethanol diacrylate by gavage (oral route) in rats.

An oral absorption is expected to be low for Triclyclodecane dimethanol diacrylate.

With a solubility of 9,78 mg/L, dermal absorption is anticipated to be low to moderate. A Log Kow of 4,64 suggests that the rate of penetration of the substance my be limited by the rate of transfer between the stratum corneum and the epidermis. However, a molecular mass smaller than 500 g/mol are favourable to a dermal absorption. The acrylates are known to bind to skin components, and this binding decreases their dermal absorption. Indeed, the dermal absorption of Triclyclodecane dimethanol diacrylate is anticipated to be low. The low dermal absorption can be confirmed in the dermal acute toxicity study, where no major systemic effect or mortality were observed in rats treated with 2000 mg/kg bw. However, Triclyclodecane dimethanol diacrylate showed allergic reaction in the GPMT: it is evidence that some uptake must have occurred although it may only have been a small fraction of the applied dose.

Based on the low value of the vapour pressure (<0.1 Pa), Triclyclodecane dimethanol diacrylate is not considered as a volatile substance. Moreover, the absorption by inhalation can be expected to be low for Triclyclodecane dimethanol diacrylate based on the values of water solubility and log kow.

 

DISTRIBUTION and METABOLISM

No specific data is available on the distribution or metabolism of Triclyclodecane dimethanol diacrylate. No organ toxicity was showed in the studies.

 

ELIMINATION

Due to the low water solubility and the low molecular mass, the excretion of Triclyclodecane dimethanol diacrylate in the urines is expected to be low. An excretion via bile and faeces is possible.