(1-methylethyl)-1,1'-biphenyl

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Screening test for acute inhalation, with significant methodological deficiencies

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Study considered as a screening, meets generally accepted scientific standards, but limited technical standard. Exposure to an aerosol, the maximum possible that was technically achievable due to the physical properties of the test material.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

25640-78-2 + 69009-90-1

IUPAC Name:

25640-78-2 + 69009-90-1

Constituent 2

Reference substance name:

(1-methylethyl)-1,1'-biphenyl + 1,1'-Biphenyl, bis(1-methylethyl)-

IUPAC Name:

(1-methylethyl)-1,1'-biphenyl + 1,1'-Biphenyl, bis(1-methylethyl)-

Test material form:

aerosol dispenser: not specified

Remarks:

migrated information: aerosol

Details on test material:

- Name of test material (as cited in study report): MIPB, isopropyl biphenyl
- Substance type: organic
- Physical state: liquid

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male

Details on test animals or test system and environmental conditions:

--

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

The animals were exposed for one hour to MIPB in a 38-liter glass inhalation chamber. The MIPB aerosol was generated into the chamber by
means of a glass nebulizer through which an airflow of 10 liters/minute was passed.

No rationale for the dosage is given.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

1 h

Concentrations:

1.67 mg/L, calculated as follows:
A total of 1001.6 mg of MIPB was generated into the exposure chamber during the one-hour period during which 600 liters of air was passed
through the chamber.

No. of animals per sex per dose:

10

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs

Statistics:

no

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LC0

Effect level:

1.67 mg/L air

Based on:

test mat.

Remarks:

nominal concentration

Exp. duration:

1 h

Mortality:

no deaths

Clinical signs:

other: During the first minute of exposure, all rats exhibited compound awareness and slight hyperactivity. After five minutes and for the remainder of the exposure period, all rats were inactive. Several animals exhibited a slight discharge around the eyes. At

Body weight:

no data

Gross pathology:

no data

Applicant's summary and conclusion

Interpretation of results:

other: not fully evaluable based on current standards

Remarks:

Criteria used for interpretation of results: expert judgment

Conclusions:

The inhalation exposure of 10 male albino rats to 1.67 mg/liter of MIPB would not appear to be toxic, since no rats died and no serious pharmacotoxic signs were observed.